Magnetic Resonance Imaging
Volume 26, Issue 10 , Pages 1334-1341 , December 2008

Evaluation of lung tumor perfusion by dynamic contrast-enhanced MRI

  • Sandra Pauls

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 731 500 61104; fax: +49 731 500 61105.
    • ,
  • Felix M. Mottaghy

      Affiliations

    • Department of Nuclear Medicine, University Hospital Gasthuisberg, KU Leuven, 3000 Leuven, Belgium
    • ,
  • Stefan A. Schmidt

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany
    • ,
  • Stefan Krüger

      Affiliations

    • Department of Internal Medicine I, University Hospital Aachen, 52057 Aachen, Germany
    • ,
  • Peter Möller

      Affiliations

    • Department of Pathology, University Hospital Ulm, 89081 Ulm, Germany
    • ,
  • Hans-Jürgen Brambs

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany
    • ,
  • Arthur Wunderlich

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany

Received 24 August 2007 ,Revised 14 April 2008 ,Accepted 14 April 2008.

References 

  1. Jeong YJ, Yi CA, Lee KS. Solitary pulmonary nodules: detection, characterization, and guidance for further diagnostic workup and treatment. AJR Am J Roentgenol. 2007;188:57–68
  2. Swensen SJ, Brown LR, Colby TV, Weaver AL, Midthun DE. Lung nodule enhancement at CT: prospective findings. Radiology. 1996;201:447–455
  3. Yi CA, Lee KS, Kim B-T, Choi JY, Kwon OJ, Kim H, et al. Tissue characterization of solitary pulmonary nodule: comparative study between helical dynamic CT and integrated PET/CT. J Nucl Med. 2006;47:443–450
  4. Scott WJ, Schwabe JL, Gupta NC, Dewan NA, Reeb SD, Sugimoto JT. Positron emission tomography of lung tumors and mediastinal lymph nodes using [18F] fluorodeoxyglucose. Ann Thorac Surg. 1994;58:698–703
  5. Hübner KF, Buonocore E, Gould HR, Thie J, Smith GT, Stephens S, et al. Differentiating benign from malignant lung lesions using “quantitative” parameters of FDG PET images. Clin Nucl Med. 1996;37:943–948
  6. Gupta N, Gill H, Graeber G, Bishop H, Hurst J, Stephens T. Dynamic positron emission tomography with F18 fluorodeoxyglucose imaging in differentiation of benign from malignant lung/mediastinal lesions. Chest. 1998;114:1105–1111
  7. Pieterman RM, van Putten JWG, Meuzelaar JJ, Mooyaart EL, Vaalburg W, Koeter GH, et al. Preoperative staging of non-small-cell lung cancer with 18-fluorodeoxyglucose positron-emission tomography. N Engl J Med. 2000;343:254–261
  8. Sagawa M, Higashi K, Sugita M, Ueda Y, Maeda S, Toga H, et al. Fluorodeoxyglucose uptake correlates with the growth pattern of small peripheral pulmonary adenocarcinoma. Srug Today. 2006;36:230–234
  9. Buck AK, Hetzel M, Schirrmeister H, Halter G, Moller P, Kratochwil C, et al. Clinical relevance of imaging proliferative activity in lung nodules. Eur J Nucl Med Mol Imaging. 2005;32:525–533
  10. Cai W, Chen K, Mohamedali KA, Cao Q, Gambhir SS, Rosenblum MG, et al. PET of vascular endothelial growth factor receptor expression. J Nucl Med. 2006;47:2048–2056
  11. Gress H, Baum U, Wolf H, Lell M, Nomayr A, Schmidt B, et al. Dose reduction in spiral-CT: detection of pulmonary coin lesions with and without anatomically adjusted modulation of tube current. Forschr Roentgenstr. 2001;173:466–470
  12. Brix G, Lechel U, Glatting G, Ziegler SI, Münzing W, Müller SP, et al. Radiation exposure of patients undergoing whole-body dual-modality [18F]-FDG PET/CT examinations. J Nucl Med. 2005;46:608–613
  13. Hintze C, Biederer J, Wenz H, Eberhardt R, Kauczor H. MRI in staging of lung cancer. Radiologe. 2006;46:251–259
  14. Ohno Y, Nogami M, Higashino T, Takenaka D, Matsumoto S, Hatabu H, et al. Prognostic value of dynamic MR imaging for non-small-cell lung cancer patients after chemoradiotherapy. J Magn Reson Imaging. 2005;21:775–783
  15. Schaefer JF, Vollmar J, Schick F, Vonthein R, Seemann MD, Aebert H, et al. Solitary pulmonary nodules: dynamic contrast-enhanced MR imaging — perfusion differences in malignant and benign lesions. Radiology. 2004;232:544–553
  16. Ostergaard L, Sorensen AG, Kwong KK, Weisskoff RM, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: experimental comparison and preliminary results. Magn Reson Med. 1996;36:726–736
  17. Daniel BL, Yen YF, Glover GH, Ikeda DM, Birdwell RL, Sawyer-Glover AM, et al. Breast disease: dynamic spiral MR imaging. Radiology,. 1998;209:499–509
  18. Taylor JS, Tofts PS, Port R, Evelhoch JL, Knopp M, Reddick WE, et al. MR imaging of tumor microcirculation: promise for the new millenium. J Magn Reson Imaging. 1999;10:903–907
  19. Pickles MD, Lowry M, Manton DJ, Gibbs P, Turnbull LW. Role of dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy. Breast Cancer Res Treat. 2005;91:1–10
  20. Workie DW, Dardzinski BJ. Quantifying dynamic contrast-enhanced MRI of the knee in children with juvenile rheumatoid arthritis using an arterial input function (AIF) extracted from popliteal artery enhancement, and the effect of the choice of the AIF on the kinetic parameters. Magn Reson Med. 2005;54:560–568
  21. Köstler H, Ritter C, Lipp M, Beer M, Hahn D, Sandstede . Prebolus quantitative MR heart perfusion imaging. Magn Reson Med. 2004;52:296–299
  22. Tsao J, Boesiger P, Pruessmann KP. k-t BLAST and k-t SENSE: dynamic MRI with high frame rate exploiting spatiotemporal correlations. Magn Reson Med. 2003;50:1031–1042
  23. Willats L, Connelly A, Calamante F. Improved deconvolution of perfusion MRI data in the presence of bolus delay and dispersion. Magn Reson Med. 2006;56:146–156
  24. Wirestam R, Andersson L, Ostergaard L, Bolling M, Aunola JP, Lindgren A, et al. Assessment of regional cerebral blood flow by dynamic susceptibility contrast MRI using different deconvolution techniques. Magn Reson Med. 2000;43:691–700
  25. Ohno Y, Hatabu H, Takenaka D, Adachi S, Kono M, Sugimura K. Solitary pulmonary nodules: potential role of dynamic MR imaging in management — initial experience. Radiology. 2002;224:503–511
  26. Fink C, Puderbach M, Bock M, Lodemann KP, Zuna I, Schmähl A, et al. Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. Radiology. 2004;231:175–184
  27. Fazio F, Wollmer P. Clinical ventilation-perfusion scintigraphy. Clin Physiol. 1981;1:323–337
  28. Miles KA, Griffiths MR, Keith CJ. Blood flow-metabolic relationships are dependent on tumour size in non-small cell lung cancer: a study using quantitative contrast-enhanced computer tomography and positron emission tomography. Eur J Nucl Med Mol Imaging. 2006;33:22–28

PII: S0730-725X(08)00137-9

doi: 10.1016/j.mri.2008.04.005

Magnetic Resonance Imaging
Volume 26, Issue 10 , Pages 1334-1341 , December 2008

Article Tools

* Image Usage & Resolution