Magnetic Resonance Imaging
Volume 26, Issue 10 , Pages 1352-1359 , December 2008

Quantification of cerebral perfusion using the “bookend technique”: an evaluation in CNS tumors

  • Timothy J. Carroll

      Affiliations

    • Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
    • Department of Radiology, Northwestern University, Chicago, IL, USA
    • Corresponding Author InformationCorresponding author. Northwestern University, Department of Radiology, 676 N. St. Clair, Suite 1400, Chicago, IL 60611, USA. Tel.: +312 926 1733; fax: +312 695 4108.
  • ,
  • Sandra Horowitz

      Affiliations

    • Department of Radiology, Northwestern University, Chicago, IL, USA
  • ,
  • Wanyong Shin

      Affiliations

    • Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
  • ,
  • Jessy Mouannes

      Affiliations

    • Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
  • ,
  • Rahul Sawlani

      Affiliations

    • Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
  • ,
  • Saad Ali

      Affiliations

    • Department of Radiology, Northwestern University, Chicago, IL, USA
  • ,
  • Jeffrey Raizer

      Affiliations

    • Department of Neurology, Northwestern University, Chicago, IL, USA
  • ,
  • Stephen Futterer

      Affiliations

    • Department of Radiology, Northwestern University, Chicago, IL, USA

Received 13 August 2007 ,Revised 7 April 2008 ,Accepted 22 April 2008.

References 

  1. Rosen BR, Belliveau JW, Vevea JM, Brady TJ. Perfusion imaging with NMR contrast agents. Magn Reson Med. 1990;14(2):249–265
  2. Rosen BR, Belliveau JW, Aronen HJ, Kennedy D, Buchbinder BR, Fischman A, et al. Susceptibility contrast imaging of cerebral blood volume: human experience. Magn Reson Med. 1991;22(2):293–299[discussion 300-293]
  3. Ostergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. Magn Reson Med. 1996;36(5):715–725
  4. Ostergaard L, Sorensen AG, Kwong KK, Weisskoff RM, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: experimental comparison and preliminary results. Magn Reson Med. 1996;36(5):726–736
  5. Pathak AP, Schmainda KM, Ward BD, Linderman JR, Rebro KJ, Greene AS. Mrderived cerebral blood volume maps: issues regarding histological validation and assessment of tumor angiogenesis. Magn Reson Med. 2001;46(4):735–747
  6. Law M, Yang S, Wang H, Babb JS, Johnson G, Cha S, et al. Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol. 2003;24(10):1989–1998
  7. Cha S. Perfusion MR imaging of brain tumors. Top Magn Reson Imaging. 2004;15(5):279–289
  8. Law M, Yang S, Babb JS, Knopp EA, Golfinos JG, Zagzag D, et al. Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol. 2004;25(5):746–755
  9. Schmainda KM, Rand SD, Joseph AM, Lund R, Ward BD, Pathak AP, et al. Characterization of a first-pass gradient-echo spin-echo method to predict brain tumor grade and angiogenesis. AJNR Am J Neuroradiol. 2004;25(9):1524–1532
  10. Cha S, Tihan T, Crawford F, Fischbein NJ, Chang S, Bollen A, et al. Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imaging. AJNR Am J Neuroradiol. 2005;26(2):266–273
  11. Law M, Oh S, Babb JS, Wang E, Inglese M, Zagzag D, et al. Lowgrade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging — prediction of patient clinical response. Radiology. 2006;238(2):658–667
  12. Boxerman JL, Schmainda KM, Weisskoff RM. Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am J Neuroradiol. 2006;27(4):859–867
  13. Sugahara T, Korogi Y, Kochi M, Ushio Y, Takahashi M. Perfusion-sensitive MR imaging of gliomas: comparison between gradient-echo and spin-echo echo-planar imaging techniques. AJNR Am J Neuroradiol. 2001;22(7):1306–1315
  14. Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR. Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med. 1994;31(6):601–610
  15. Sorensen AG, Reimer P. Cerebral Perfusion Imaging. Principles and Current Applications. Georg Thieme Verlag; 2000;
  16. Sakaie KE, Shin W, Curtin KR, McCarthy RM, Cashen TA, Carroll TJ. Method for improving the accuracy of quantitative cerebral perfusion imaging. J Magn Reson Imaging. 2005;21(5):512–519
  17. Shin W, Cashen TA, Horowitz SW, Sawlani R, Carroll TJ. Quantitative CBV measurement from static T1 changes in tissue and correction for intravascular water exchange. Magn Reson Med. 2006;56(1):138–145
  18. Shin W, Horowitz SW, Ragin A, Chen Y, Walker MT, Carroll TJ. Quantitative cerebral perfusion using MRI imaging: an evaluation of reproducibility and age dependence. Magn Reson Med. 2007;58(6):1232–1241
  19. Shin W, Ali S, Bhatt H, Shaibani A, Carroll TJ. In: Quantitative cerebral blood flow measurement in a canine stroke model: validation with regional blood flow measurement using flourescent microspheres. Berlin, Germany; 2007;p. 590
  20. Sodickson DK, Manning WJ. Simultaneous acquisition of spatial harmonics (SMASH): fast imaging with radiofrequency coil arrays. Magn Reson Med. 1997;38(4):591–603
  21. Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med. 1999;42(5):952–962
  22. Griswold MA, Jakob PM, Heidemann RM, Nittka M, Jellus V, Wang J, et al. Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med. 2002;47(6):1202–1210
  23. Moseley ME, Chew WM, White DL, Kucharczyk J, Litt L, Derugin N, et al. Hypercarbia-induced changes in cerebral blood volume in the cat: a 1H MRI and intravascular contrast agent study. Magn Reson Med. 1992;23(1):21–30
  24. Kuppusamy K, Lin W, Cizek GR, Haacke EM. In vivo regional cerebral blood volume: quantitative assessment with 3D T1-weighted pre- and postcontrast MR imaging. Radiology. 1996;201(1):106–112
  25. Kim YR, Rebro KJ, Schmainda KM. Water exchange and inflow affect the accuracy of T1-GRE blood volume measurements: implications for the evaluation of tumor angiogenesis. Magn Reson Med. 2002;47(6):1110–1120
  26. Rempp KA, Brix G, Wenz F, Becker CR, Guckel F, Lorenz WJ. Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging. Radiology. 1994;193(3):637–641
  27. Hazlewood CF, Chang DC, Nichols BL, Woessner DE. Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Biophys J. 1974;14(8):583–606
  28. Donahue KM, Weisskoff RM, Chesler DA, Kwong KK, Bogdanov AA, Mandeville JB, et al. Improving MR quantification of regional blood volume with intravascular T1 contrast agents: accuracy, precision, and water exchange. Magn Reson Med. 1996;36(6):858–867
  29. Carroll TJ, Rowley HA, Haughton VM. Automatic calculation of the arterial input function for cerebral perfusion imaging with MR imaging. Radiology. 2003;227(2):593–600
  30. Look DC, Locker DR. Time saving in measurement of NMR and EPR relaxation time. Rev Sci Intrum. 1970;41(2):250–251
  31. Frackowiak RS, Lenzi GL, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr. 1980;4(6):727–736
  32. Pantano P, Baron JC, Lebrun-Grandie P, Duquesnoy N, Bousser MG, Comar D. Regional cerebral blood flow and oxygen consumption in human aging. Stroke. 1984;15(4):635–641
  33. Shin W, Carroll TJ. A self calibrating pulse sequence for real time quantitative cerebral perfusion. Proc Int Soc Magn Reson Med. 2007;

PII: S0730-725X(08)00142-2

doi: 10.1016/j.mri.2008.04.010

Magnetic Resonance Imaging
Volume 26, Issue 10 , Pages 1352-1359 , December 2008