Magnetic Resonance Imaging
Volume 27, Issue 9 , Pages 1216-1222, November 2009

Quantitative permeability magnetic resonance imaging in acute ischemic stroke: how long do we need to scan?

  • Logi Vidarsson

      Affiliations

    • Department of Diagnostic Imaging, The Hospital for Sick Children and The University of Toronto, Toronto, ON, Canada
    • Corresponding Author InformationCorresponding author.
    • ,
  • Rebecca E. Thornhill

      Affiliations

    • Department of Medical Imaging, The University of Toronto, Toronto, ON, Canada
    • ,
  • Fang Liu

      Affiliations

    • Department of Diagnostic Imaging, The Hospital for Sick Children and The University of Toronto, Toronto, ON, Canada
    • ,
  • David J. Mikulis

      Affiliations

    • Department of Medical Imaging, The Toronto Western Hospital, Toronto, ON, Canada
    • ,
  • Andrea Kassner

      Affiliations

    • Department of Diagnostic Imaging, The Hospital for Sick Children and The University of Toronto, Toronto, ON, Canada
    • Department of Medical Imaging, The University of Toronto, Toronto, ON, Canada

Received 9 September 2008; received in revised form 9 December 2008; accepted 26 January 2009. published online 20 August 2009.

Abstract 

Blood–brain barrier (BBB) permeability estimation with dynamic contrast-enhanced MRI (DCE-MRI) has shown significant potential for predicting hemorrhagic transformation (HT) in patients presenting with acute ischemic stroke (AIS). In this work, the effects of scan duration on quantitative BBB permeability estimates (KPS) were investigated. Data from eight patients (three with HT) aged 37–93 years old were retrospectively studied by directly calculating the standard deviation of KPS as a function of scan time. The uncertainty in KPS was reduced only slightly for a scan time of 3 min and 30 s (4% reduction in P value from .047 to .045). When more than 3 min and 30 s of data were used, quantitative permeability MRI was able to separate those patients who proceeded to HT from those who did not (P value <.05). Our findings indicate that reducing permeability acquisition times is feasible in keeping with the need to maintain time-efficient MR protocols in the setting of AIS.

Keywords: DCE-MRI, Stroke, Quantitative permeability analysis

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PII: S0730-725X(09)00036-8

doi:10.1016/j.mri.2009.01.019

Magnetic Resonance Imaging
Volume 27, Issue 9 , Pages 1216-1222, November 2009

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