Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T☆
Received 15 January 2009; received in revised form 20 April 2009; accepted 7 May 2009. published online 06 July 2009.
Abstract
Magnetic Resonance Spectroscopic Imaging (MRSI) is a technique for imaging spatial variation of metabolites and has been very useful in characterizing biochemical changes associated with disease as well as response to therapy in malignant pathologies. This work presents a self-calibrated undersampling to accelerate 3D elliptical MRSI and an extrapolation-reconstruction algorithm based on the GRAPPA method. The accelerated MRSI technique was tested in three volunteers and five brain tumor patients. Acceleration allowed larger spatial coverage and consequently, less lipid contamination in spectra, compared to fully sampled acquisition within the same scantime. Metabolite concentrations measured from the accelerated acquisitions were in good agreement with measurements obtained from fully sampled MRSI scans.
aRadiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
bJoint Graduate Group in Bioengineering, University of California, San Francisco, and University of California, Berkeley, Berkeley CA 94720 and San Francisco, CA 94158, USA
Corresponding author. GE Healthcare Applied Science Lab, Menlo Park, CA 94025, USA. Tel.: +1 415 290 2197.
☆ This work has been presented in part at the 28th Annual Meeting of IEEE EMBS, New York, USA, 2006, and the 15th Annual Meeting of ISMRM , Berlin, Germany, 2007.
ABSTRACT