Magnetic Resonance Imaging
Volume 27, Issue 10 , Pages 1319-1325, December 2009

Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T☆

  • Suchandrima Banerjee

      Affiliations

    • Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    • Corresponding Author InformationCorresponding author. GE Healthcare Applied Science Lab, Menlo Park, CA 94025, USA. Tel.: +1 415 290 2197.
    • ,
  • Esin Ozturk-Isik

      Affiliations

    • Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    • ,
  • Sarah J. Nelson

      Affiliations

    • Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    • Joint Graduate Group in Bioengineering, University of California, San Francisco, and University of California, Berkeley, Berkeley CA 94720 and San Francisco, CA 94158, USA
    • ,
  • Sharmila Majumdar

      Affiliations

    • Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    • Joint Graduate Group in Bioengineering, University of California, San Francisco, and University of California, Berkeley, Berkeley CA 94720 and San Francisco, CA 94158, USA

Received 15 January 2009; received in revised form 20 April 2009; accepted 7 May 2009. published online 06 July 2009.

Abstract 

Magnetic Resonance Spectroscopic Imaging (MRSI) is a technique for imaging spatial variation of metabolites and has been very useful in characterizing biochemical changes associated with disease as well as response to therapy in malignant pathologies. This work presents a self-calibrated undersampling to accelerate 3D elliptical MRSI and an extrapolation-reconstruction algorithm based on the GRAPPA method. The accelerated MRSI technique was tested in three volunteers and five brain tumor patients. Acceleration allowed larger spatial coverage and consequently, less lipid contamination in spectra, compared to fully sampled acquisition within the same scantime. Metabolite concentrations measured from the accelerated acquisitions were in good agreement with measurements obtained from fully sampled MRSI scans.

Keywords: Elliptical MRI, GRAPPA, Brain tumors

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☆ This work has been presented in part at the 28th Annual Meeting of IEEE EMBS, New York, USA, 2006, and the 15th Annual Meeting of ISMRM , Berlin, Germany, 2007.

PII: S0730-725X(09)00118-0

doi:10.1016/j.mri.2009.05.031

Magnetic Resonance Imaging
Volume 27, Issue 10 , Pages 1319-1325, December 2009

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