Quantitative assessment of regional systolic and diastolic functions and temporal heterogeneity of myocardial contraction in patients with myocardial infarction using cine magnetic resonance imaging and Fourier fitting

Natsume, Takahiro; Amano, Tomoyasu; Takehara, Yasuo; Ichihara, Takashi; Takeda, Kan; Sakuma, Hajime

doi:10.1016/j.mri.2009.05.043

« Previous Next »Magnetic Resonance Imaging
Volume 27, Issue 10 , Pages 1440-1446, December 2009

Quantitative assessment of regional systolic and diastolic functions and temporal heterogeneity of myocardial contraction in patients with myocardial infarction using cine magnetic resonance imaging and Fourier fitting

Takahiro Natsume
- Diagnostic Imaging Center, Seirei Mikatahara General Hospital, Hamamatsu, Shizuoka 433-8558, Japan
- Department of Radiology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
- Corresponding author. Tel.: +81 53 436 1251 (3300); fax: +81 53 439 6896.
Tomoyasu Amano
- Diagnostic Imaging Center, Seirei Mikatahara General Hospital, Hamamatsu, Shizuoka 433-8558, Japan
Yasuo Takehara
- Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan
Takashi Ichihara
- Faculty of Radiological Technology, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan
- Department of Radiology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
Kan Takeda
- Department of Radiology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
Hajime Sakuma
- Department of Radiology, Mie University School of Medicine, Tsu, Mie 514-8507, Japan

Received 6 February 2009; received in revised form 9 May 2009; accepted 10 May 2009. published online 06 July 2009.

Abstract

Purpose

The objective of this study is to determine regional left ventricle (LV) function and temporal heterogeneity of LV wall contraction by analyzing regional time–volume curve (TVC) after Fourier fitting and to assess altered systolic and diastolic functions and temporal indices of myocardial contraction in infarcted segments in comparison with noninfarcted myocardium in patients with myocardial infarction (MI).

Methods

Steady-state cine magnetic resonance (MR) and late gadolinium-enhanced (LGE) MR images were acquired using a 1.5-T MR system in 60 patients with MI. Regional LV function was determined by analyzing regional TVC in 16 segments. The fitted regional TVC was generated by Fourier curve fitting with five harmonics. Regional LV ejection fraction (EF), peak ejection rate (PER), peak filling rate (PFR), time to end-systole and time to peak filling (TPF) were determined from TVC and the first derivative curve.

Results

On LGE MR imaging (MRI), MI was observed in 307 of 960 segments (32.0%). Regional EF and PER averaged in LGE segments were 49.3±14.5% and 2.83±0.65 end-diastolic volume (EDV)/s, significantly lower than those in normal segments (66.7±11.9% and 3.63±0.60 EDV/s, P<.001 and P<.01, respectively). In addition, regional PFR, an index of diastolic function, was significantly reduced in LGE segments (1.94±0.54 vs. 2.86±0.68 EDV/s, P<.01). Time to end-systole and TPF were significantly greater in LGE segments (380.2±57.6 and 169.3±45.4 ms) than in normal segments (300.9±55.1 and 132.3±43.0 ms, P<.01 and P<.01, respectively).

Conclusions

Analysis of regional TVC on cine MRI after Fourier fitting allows quantitative assessment of regional systolic and diastolic LV functions and temporal heterogeneity of LV wall contraction in patients with MI.

Keywords: Cardiac MR imaging, Left ventricle, Regional function, Quantitative analysis