Magnetic Resonance Imaging
Volume 28, Issue 2 , Pages 153-162 , February 2010

Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer

  • Janine M. Lupo

      Affiliations

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    • Corresponding Author InformationCorresponding author. UCSF Radiology, Box 2532, San Francisco, CA 94158-2532, USA. Tel.: +1 415 514 4420; fax: +1 415 514 2550.
    • ,
  • Albert P. Chen

      Affiliations

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    • ,
  • Matthew L. Zierhut

      Affiliations

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    • UCSF/UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, CA 94158, USA
    • ,
  • Robert A. Bok

      Affiliations

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    • ,
  • Charles H. Cunningham

      Affiliations

    • Department of Medical Biophysics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M56 2M9
    • ,
  • John Kurhanewicz

      Affiliations

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    • Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA
    • ,
  • Daniel B. Vigneron

      Affiliations

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    • Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA
    • ,
  • Sarah J. Nelson

      Affiliations

    • Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    • Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA

Received 5 February 2009 ,Revised 12 May 2009 ,Accepted 4 July 2009.

References 

  1. Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med. 2008;49(Suppl 2):24S–42S
  2. Kurhanewicz J, Bok R, Nelson SJ, Vigneron DB. Current and potential applications of clinical 13C MR spectroscopy. J Nucl Med. 2008;49(3):341–344
  3. Swanson MG, Zektzer AS, Tabatabai ZL, Simko J, Jarso S, Keshari KR, et al. Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy. Magn Reson Med. 2006;55(6):1257–1264
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  6. Tessem MB, Swanson MG, Keshari KR, et al. Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Magn Reson Med. 2008;60(3):510–516
  7. Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, et al. Metastatic prostate cancer in a transgenic mouse. Cancer Res. 1996;56(18):4096–4102
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  9. Kaplan-Lefko PJ, Chen TM, Ittmann MM, Barrios RJ, Ayala GE, Huss WJ, et al. Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model. Prostate. 2003;55(3):219–237
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  11. Golman K, Zandt RI, Lerche M, Pehrson R, Ardenkjaer-Larsen JH. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res. 2006;66(22):10855–10860
  12. Mansson S, Johansson E, Magnusson P, Chai CM, Hansson G, Petersson JS, et al. 13C Imaging—a new diagnostic platform. Eur Radiol. 2006;16(1):57–67
  13. Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, et al. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T—initial experience. Magn Reson Med. 2007;58(6):1099–1106
  14. Kohler SJ, Yen Y, Wolber J, Chen AP, Albers MJ, Bok R, et al. In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate. Magn Reson Med. 2007;58(1):65–69
  15. Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen YF, et al. Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson. 2007;187(2):357–362
  16. Albers M, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, et al. Hyperpolarized 13C lactate, pyruvate, and alanine — non-invasive biomarkers for prostate cancer detection and staging. Cancer Res. 2008;68(20):8607–8615
  17. Cunningham CH, Chen AP, Lustig M, Hargreaves BA, Lupo J, Xu D, et al. Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J Magn Reson. 2008;193(1):139–146
  18. Chen AP, Hurd RE, Cunningham CH, Li Y, Ziehurt ML, Bok R, et al. Spatially resolved 13C hyperpolarized dynamic MRS using a flyback echo-planar readout trajectory. In: Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, March 9-14. 2008;p. 60
  19. Zhao L, Mulkern R, Tseng CH, Williamson D, Patz S, Kraft R, et al. Gradient-echo imaging considerations for hyperpolarized 129Xe MR. J Magn Reson B. 1996;113:179–183
  20. Chen AP, Hurd RE, Cunningham CH, Albers M, Zierhut ML, Yen YF, et al. Symmetric echo acquisition of hyperpolarized C-13 MRSI data in the TRAMP mouse at 3T. In: Proceedings of the International Society of Magnetic Resonance in Medicine, Berlin, Germany, May 19-26. 2007;p. 538
  21. Nelson SJ. Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors. Magn Reson Med. 2001;46(2):228–239
  22. Cunningham CH, Vigneron DB, Chen AP, Xu D, Nelson SJ, Hurd RE, et al. Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging. Magn Reson Med. 2005;54(5):1286–1289
  23. Kohler SJ, Yen Y, Wolber J, Chen AP, Albers MJ, Bok R, et al. In vivo (13)carbon metabolic imaging at 3T with hyperpolarized (13)C-1-pyruvate. Magn Reson Med. 2007;58(1):65–69
  24. Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J, et al. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med. 2007;13(11):1382–1387

 This article was presented in part at the 16th Annual Meeting of ISMRM, Toronto, Ontario, Canada, 2008.

☆ This research was supported by NIH grants R01-EB007588, R21-EB005363 and R01-CA111291, and UC Discovery grants LSIT01-10107 and ITL-BIO04-10148 in conjunction with GE Healthcare.

PII: S0730-725X(09)00180-5

doi: 10.1016/j.mri.2009.07.007

Magnetic Resonance Imaging
Volume 28, Issue 2 , Pages 153-162 , February 2010

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