EEG topography-specific BOLD changes: a continuous EEG-fMRI study in a patient with focal epilepsy

Cosottini, Mirco; Pesaresi, Ilaria; Maritato, Patrizia; Belmonte, Gina; Taddei, Arianna; Sartucci, Ferdinando; Mascalchi, Mario; Murri, Luigi

doi:10.1016/j.mri.2009.11.011

« Previous Next »Magnetic Resonance Imaging
Volume 28, Issue 3 , Pages 388-393, April 2010

EEG topography-specific BOLD changes: a continuous EEG-fMRI study in a patient with focal epilepsy

Mirco Cosottini
- Department of Neuroscience University of Pisa, 56100 Pisa, Italy
- Corresponding author. S. Chiara Hospital, 56100 Pisa, Italy. Tel.: +39 050992722; fax: +39 050992127.
Ilaria Pesaresi
- Department of Radiology University of Pisa, 56100 Pisa, Italy
Patrizia Maritato
- Department of Neuroscience University of Pisa, 56100 Pisa, Italy
Gina Belmonte
- Medical Physics University of Pisa, 56100 Pisa, Italy
Arianna Taddei
- Department of Neuroscience University of Pisa, 56100 Pisa, Italy
Ferdinando Sartucci
- Department of Neuroscience University of Pisa, 56100 Pisa, Italy
Mario Mascalchi
- Department of Clinical Physiopathology, University of Florence, 50134 Florence, Italy
Luigi Murri
- Department of Neuroscience University of Pisa, 56100 Pisa, Italy

Received 26 June 2009; received in revised form 11 August 2009; accepted 27 November 2009. published online 14 January 2010.

Abstract

Blood oxygenation level dependent (BOLD) response related to interictal activity was evaluated in a patient with post-traumatic focal epilepsy at repeated continuous electroencephalogram (EEG)-functional magnetic resonance imaging examinations. Lateralized interictal EEG activity induced a main cluster of activation co-localized with the anatomical lesion. Spreading of EEG interictal activity to both frontal lobes evoked bilateral clusters of activation indicating that topography of BOLD response might depend on the spatial distribution of epileptiform activity.

Keywords: Focal epilepsy, Interictal epileptiform activity, Continuous EEG-fMRI, BOLD response