Magnetic Resonance Imaging
Volume 28, Issue 4 , Pages 487-494 , May 2010

Experimental hypoxic–ischemic encephalopathy: comparison of apparent diffusion coefficients and proton magnetic resonance spectroscopy

  • Yang-Kang Li

      Affiliations

    • Department of Radiology, Cancer Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 0754 88555844; fax: +86 0754 88535687.
  • ,
  • Guo-Rui Liu

      Affiliations

    • Department of Medical Imaging, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China
  • ,
  • Xiu-Guo Zhou

      Affiliations

    • Department of Radiology, Cancer Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
  • ,
  • Ai-Qun Cai

      Affiliations

    • Department of Radiology, Cancer Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China

Received 21 January 2009 ,Revised 9 October 2009 ,Accepted 6 December 2009.

References 

  1. Robertson RL, Ben-Sira L, Barnes PD, Mulkern RV, Robson CD, Maier SE, et al. MR line-scan diffusion-weighted imaging of term neonates with perinatal brain ischemia. AJNR Am J Neuroradiol. 1999;20:1658–1670
  2. Barkovich AJ, Westmark KD, Bedi HS, Partridge JC, Ferriero DM, Vigneron DB. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report. AJNR Am J Neuroradiol. 2001;22:1786–1794
  3. Cowan FM, Pennock JM, Hanrahan JD, Manji KP, Edwards AD. Early detection of cerebral infarction and hypoxic ischemic encephalopathy in neonates using diffusion-weighted magnetic resonance imaging. Neuropediatrics. 1994;25:172–175
  4. Forbes KPN, Pipe JG, Bird R. Neonatal hypoxic-ischemic encephalopathy: detection with diffusion-weighted MR imaging. AJNR Am J Neuroradiol. 2000;21:1490–1496
  5. Wolf RL, Zimmerman RA, Clancy R, Haselgrove JH. Quantitative apparent diffusion coefficient measurements in term neonates for early detection of hypoxic-ischemic brain injury: initial experience. Radiology. 2001;218:825–833
  6. Roelants-Van Rijn AM, van der Grond J, de Vries LS, Groenendaal F. Value of 1H-MRS using different echo times in neonates with cerebral hypoxia-ischemia. Pediatr Res. 2001;49:356–362
  7. Groenendaal F, Veenhoven RH, Van Der Grond J, Jansen GH, Witkamp TD, De Vries LS. Cerebral lactate and N-acetyl-aspartate/choline ratios in asphyxiated full-term neonates demonstrated in vivo using proton magnetic resonance spectroscopy. Pediatr Res. 1997;35:148–151
  8. Yata K, Matchett GA, Tsubokawa T, Tang J, Kanamaru K, Zhang JH. Granulocyte-colony stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats. Brain Res. 2007;1145:227–238
  9. Cheng Y, Liu GR, Guan JT, Guo YL, Li YK, Wu RH. Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy. Postgrad Med J. 2005;81:589–593
  10. Pulera MR, Adams LM, Liu H, Santos DG, Nishimura RN, Yang F, et al. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke. 1998;29:2622–2630
  11. Miyasaka N, Kuroiwa T, Zhao FY, Nagaoka T, Akimoto H, Yamada I, et al. Cerebral ischemic hypoxia: discrepancy between apparent diffusion coefficients and histologic changes in rats. Radiology. 2000;215:199–204
  12. Li FH, Liu KF, Silva MD, Meng XJ, Gerriets T, Helmer KG, et al. Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats. AJNR Am J Neuroradiol. 2002;23:180–188
  13. Aito H, Aalto KT, Raivio KO. Biphasic ATP depletion caused by transient oxidative exposure is associated with apoptotic cell death in rat embryonal cortical neurons. Pediatr Res. 2002;52:40–45
  14. Bhakoo KK, Craig TJ, Styles P. Developmental and regional distribution of aspartoacylase in rat brain tissue. J Neurochem. 2001;79:211–220
  15. Rudkin TM, Arnold DL. Proton magnetic resonance spectroscopy for the diagnosis and management of cerebral disorders. Arch Neurol. 1999;56:919–926
  16. Hüppi PS, Lazeyras F. Proton magnetic resonance spectroscopy (1H-MRS) in neonatal brain injury. Pediatr Res. 2001;49:317–320
  17. Bhakoo KK, Pearce D. In vitro expression of N-acetyl aspartate by oligodendrocytes implications for proton magnetic resonance spectroscopy signal in vivo. J Neurochem. 2000;74:254–262
  18. Davie CA, Hawkins CP, Barker GJ, Brennan A, Tofts PS, Miller DH, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain. 1994;117:49–58
  19. Narayana PA, Doyle TJ, Lai D, Wolinsky JS. Serial proton magnetic resonance spectroscopic imaging, contrast-en-hanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol. 1998;43:56–71
  20. Thornton JS, Ordidge RJ, Penrice J, Cady EB, Amess PN, Punwani S, et al. Anistropic water diffusion in white and gray matter of the neonatal piglet brain before and after transient hypoxia-ischemia. MRI. 1997;15:433–440
  21. Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB. Inhibition of N-acetylaspartate production: implications for 1HMRS studies in vivo. Neuroreport. 1996;7:1397–1400
  22. Yang GY, Betz AL, Chenevert TL, Brunberg JA, Hoff JT. Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg. 1994;81:93–102
  23. Kimelberg HK. Current concepts of brain edema. Review of laboratory investigations. J Neurosurg. 1995;83:1051–1059
  24. Rozental R, Giaumc C, Spray DC. Gap junctions in the nervous system. Brain Res. 2000;32:11–15
  25. Bezzi P, Volterra A. A neuron-glia signalling network in the active brain. Curr Opin Neurobil. 2001;11:387–394
  26. Nedergaard M. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science. 1994;263:1768–1771
  27. Robinson SR, Hampson EC, Munro MN, Vaney DI. Unidirectional coupling of gap junctions between neuroglia. Science. 1993;262:1072–1074
  28. Feder ME, Hofmann GE. Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol. 1999;l61:243–282
  29. Russo A, Palumbo M, Scifo C, Cardile V, Barcellona ML, Renis M. Ethanol-induced oxidative stress in rat astrocytes: role of HSP70. Cell Biol Toxicol. 2001;17:153–168
  30. Ritossa F. Discovery of the heat shock response. Cell Stress Chaperones. 1996;1:97–98
  31. Roth SC, Baudin J, Cady E, Johal K, Townsend JP, Wyatt JS, et al. Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years. Dev Med Child Neurol. 1997;39:718–725
  32. van Cappellen van Walsum AM, Jongsma HW, Wevers RA, Nijhuis JG, Crevels J, Ehgelke UFH, et al. 1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery. Pediatr Res. 2002;52:56–63

PII: S0730-725X(09)00294-X

doi: 10.1016/j.mri.2009.12.002

Magnetic Resonance Imaging
Volume 28, Issue 4 , Pages 487-494 , May 2010