Magnetic Resonance Imaging
Volume 28, Issue 4 , Pages 466-476 , May 2010

Neural and vascular variability and the fMRI-BOLD response in normal aging

  • Sridhar S. Kannurpatti

      Affiliations

    • Department of Radiology, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA
    • ,
  • Michael A. Motes

      Affiliations

    • School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA
    • ,
  • Bart Rypma

      Affiliations

    • School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA
    • ,
  • Bharat B. Biswal

      Affiliations

    • Department of Radiology, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 973 972 7498; fax: +1 973 972 7363.

Received 10 June 2009 ,Revised 6 October 2009 ,Accepted 6 December 2009.

References 

  1. D'Esposito M, Deouell LY, Gazzaley A. Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging. Nat Rev Neurosci. 2003;4:863–872
  2. Farkas E, Luiten PG. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol. 2001;64:575–611
  3. Ross MH, Yurgelun-Todd DA, Renshaw PF, Maas LC, Mendelson JH, Mello NK, et al. Age-related reduction in functional MRI response to photic stimulation. Neurology. 1997;48:173–176
  4. Huettel SA, Singerman JD, McCarthy G. The effects of aging upon the hemodynamic response measured by functional MRI. Neuroimage. 2001;13:161–175
  5. Buckner RL, Snyder AZ, Sanders AL, Raichle ME, Morris JC. Functional brain imaging of young, nondemented, and demented older adults. J Cogn Neurosci. 2000;2:24–34
  6. Riecker A, Grodd W, Klose U, Schulz JB, Gröschel K, Erb M, et al. Relation between regional functional MRI activation and vascular reactivity to carbon dioxide during normal aging. J Cereb Blood Flow Metab. 2003;23:565–573
  7. Yamamoto M, Meyer JS, Sakai F, Yamaguchi F. Aging and cerebral vasodilator responses to hypercarbia: responses in normal aging and in persons with risk factors for stroke. Arch Neurol. 1980;37:489–496
  8. Fang HCH. Observation of aging characteristics of cerebral blood vessels: macroscopic and microscopic features. In:  Terry RD,  Gershon S editor. Neurobiology of aging. NewYork: Raven; 1976;
  9. Kalaria RN. Cerebral vessels in ageing and Alzheimer's disease. Pharmacol Ther. 1996;72:193–214
  10. Rypma B, D'Esposito M. Age-related changes in brain-behavior relationships:Evidence from event-related functional MRI studies. Eur J Cog Psychol. 2001;13:235–256
  11. Taoka T, Iwasaki S, Uchida H, Fukusumi A, Nakagawa H, Kichikawa K, et al. Age correlation of the time lag in signal change on EPI-fMRI. J Comput Assist Tomogr. 1998;22:514–517
  12. D'Esposito M, Zarahn E, Aguirre GK, Rypma B. The effect of normal aging on the coupling of neural activity to the bold hemodynamic response. Neuroimage. 1999;10:6–14
  13. Hesselmann V, Weber OZ, Wedekind C, Krings T, Schulte O, Kugel H, et al. Age related signal decrease in functional magnetic resonance imaging during motor stimulation in humans. Neurosci Lett. 2001;308:141–144
  14. Mattay VS, Fera F, Tessitore A, Hariri AR, Berman KF, Das S, et al. Neurophysiological correlates of age-related changes in working memory capacity. Neurosci Lett. 2002;392:32–37
  15. Riecker A, Gröschel K, Ackermann H, Steinbrink C, Witte O, Kastrup A. Functional significance of age-related differences in motor activation patterns. Neuroimage. 2006;32:1345–1354
  16. Heuninckx S, Wenderoth N, Swinnen SP. Systems neuroplasticity in the aging brain: recruiting additional neural resources for successful motor performance in elderly persons. J Neurosci. 2008;28:91–99
  17. Rypma B, Berger JS, Prabhakaran V, Bly BM, Kimberg DY, Biswal BB, et al. Neural correlates of cognitive efficiency. Neuroimage. 2006;33:969–979
  18. Biswal BB, Kannurpatti SS, Rypma B. Hemodynamic scaling of fMRI-BOLD signal: validation of low-frequency spectral amplitude as a scalability factor. Magn Reson Imaging. 2007;25:1358–1369
  19. Samanez-Larkin GR, D'Esposito M. Group comparisons: imaging the aging brain. Soc Cogn Affect Neurosci. 2008;3:290–297
  20. Thomason ME, Foland LC, Glover GH. Calibration of BOLD fMRI using breath holding reduces group variance during a cognitive task. Hum Brain Mapp. 2007;28:59–68[Imaging 2007;25:1358-1369]
  21. Kannurpatti SS, Biswal BB. Detection and scaling of task-induced fMRI-BOLD response using resting state fluctuations. Neuroimage. 2008;40:1567–1574
  22. Kannurpatti SS, Biswal BB, Hudetz AG. Differential fMRI-BOLD signal response to apnea in humans and anesthetized rats. Magn Reson Med. 2002;47:864–870
  23. Wechsler D. Manual for the Wechsler Adult Intelligence Scale-Revised (WAIS-R). New York: The Psychological Corp; 1981;
  24. Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996;29:162–173
  25. Jiang A, Kennedy DN, Baker JR, Weisskoff RM, Tootell RBH, Woods RP, et al. Motion detection and correction in functional MR imaging. Human Brain Mapp. 1995;3:224–235
  26. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS. Processing strategies for the time-course data sets in fMRI of the human brain. Mag Reson Med. 1993;30:161–173
  27. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. New York: George Theime Verlag; 1988;
  28. Murphy K, Birn RM, Handwerker DA, Jones TB, Bandettini PA. The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?. Neuroimage. 2009;44:893–905
  29. Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation maximization algorithm. IEEE Trans Med Imaging. 2001;20:45–57
  30. Bandettini PA, Wong EC. A hypercapnia-based normalization method for improved spatial localization of human brain activation with fMRI. NMR Biomed. 1997;10:197–203
  31. Cohen ER, Rostrup E, Sidaros K, Lund TE, Paulson OB, Ugurbil K, et al. Hypercapnic normalization of BOLD fMRI: comparison across field strengths and pulse sequences. Neuroimage. 2004;23:613–624
  32. Handwerker DA, Gazzaley A, Inglis BA, D'Esposito M. Reducing vascular variability of fMRI data across aging populations using a breathholding task. Hum Brain Mapp. 2007;28:846–859
  33. Kastrup A, Kruger G, Glover GH, Mosley EM. Assessment of cerebral oxidative metabolism with breath-holding and fMRI. Mag Reson Med. 1999;42:608–611
  34. Li QT, Kastrup A, Takahashi A, Glover GH, Mosley EM. Functional MRI of human brain during breath-holding by BOLD and FAIR techniques. Neuroimage. 1999;9:243–249
  35. Raz N. Aging of the brain and its impact on cognitive performance: integration of structural and functional findings. In:  Craik FIM,  Salthouse TA editor. Handbook of aging and cognition II. Mahwah (NJ): Erlbaum; 2000;p. 1–90
  36. Raz N, Lindenberger U, Rodrigue KM, Kennedy KM, Head D, Williamson A, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex. 2005;15:1676–1689
  37. Rypma B, Prabhakaran V, Desmond JE, Gabrieli JDE. Age differences in prefrontal cortical activity in working memory. Psychol Aging. 2001;16:371–384
  38. Cabeza R, Anderson ND, Locantore JK, McIntosh AR. Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage. 2002;17:1394–1402
  39. Rypma B. A neural efficiency hypothesis of age-related changes in human working memory performance. In:  Osaka N,  Logie R,  D'Esposito M editor. The cognitive neuroscience of working memory. Oxford (UK): Oxford University Press; 2007;
  40. Salthouse TA. Independence of age-related influences on cognitive abilities across the life span. Dev Psychol. 1998;34:851–864
  41. Rypma B, Berger JS, Genova HM, Rebbechi D, D'Esposito M. Dissociating age-related changes in cognitive strategy and neural efficiency using event-related fMRI. Cortex. 2005;41:582–594

PII: S0730-725X(09)00299-9

doi: 10.1016/j.mri.2009.12.007

Magnetic Resonance Imaging
Volume 28, Issue 4 , Pages 466-476 , May 2010

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