Detection of bone metastases using diffusion weighted magnetic resonance imaging: comparison with 11C-methionine PET and bone scintigraphy

Goudarzi, Behnaz; Kishimoto, Riwa; Komatsu, Shuhei; Ishikawa, Hiroyuki; Yoshikawa, Kyosan; Kandatsu, Susumu; Obata, Takayuki

doi:10.1016/j.mri.2009.12.008

« Previous Next »Magnetic Resonance Imaging
Volume 28, Issue 3 , Pages 372-379, April 2010

Detection of bone metastases using diffusion weighted magnetic resonance imaging: comparison with ¹¹C-methionine PET and bone scintigraphy

Behnaz Goudarzi
- Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan
- Current address: Radiology Department, Nuclear Medicine Division, Johns Hopkins University, Baltimore, Maryland.
Riwa Kishimoto
- Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan
- Corresponding author. Tel.: +81 43 206 3360x6215; fax: +81 43 206 3370.
Shuhei Komatsu
- Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan
Hiroyuki Ishikawa
- Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan
Kyosan Yoshikawa
- Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan
Susumu Kandatsu
- Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan
Takayuki Obata
- Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan

Received 25 May 2009; received in revised form 19 October 2009; accepted 6 December 2009. published online 28 January 2010.

Abstract

Purpose

We evaluated the ability of diffusion-weighted imaging (DWI) to detect bone metastasis by comparing the results obtained using this modality with those obtained using ¹¹C-methionine (MET) positron emission tomography (PET) and bone scintigraphy.

Materials and methods

This retrospective study involved 29 patients with bone metastasis. DWI was obtained using a single-shot echo planar imaging (EPI) sequence with fat suppression using a short inversion time inversion recovery sequence. The detection capabilities of DWI for bone metastases were compared with those of whole body MET PET (in 19 patients) and 99mTc-methylene diphosphonate bone scintigraphy (in 15 patients).

Results

Among the 19 patients who were diagnosed using DWI and PET, the PET identified 39 bone metastases, while the DWI identified 60 metastases out of 69 metastases revealed with conventional magnetic resonance imaging (MRI). Among the 15 patients who were diagnosed using DWI and bone scintigraphy, the bone scintigraphy identified 18 bone metastases, while the DWI identified 72 metastases out of 78 metastases revealed with conventional MRI. The overall bone metastasis detection rates were 56.5% for PET, 23.1% for bone scintigraphy and 92.3% for DWI.