Magnetic Resonance Imaging
Volume 28, Issue 8 , Pages 1087-1094 , October 2010

Coupling of neural activity and fMRI-BOLD in the motion area MT

  • Michael T. Lippert

      Affiliations

    • Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 Tübingen, Germany
    • Corresponding Author InformationCorresponding author.
  • ,
  • Thomas Steudel

      Affiliations

    • Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 Tübingen, Germany
  • ,
  • Frank Ohl

      Affiliations

    • Leibniz-Institute for Neurobiology, Brenneckestraße 6, 39118 Magdeburg, Germany
  • ,
  • Nikos K. Logothetis

      Affiliations

    • Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 Tübingen, Germany
    • Division of Imaging Science and Biomedical Engineering, University of Manchester, M13 9PT Manchester, United Kingdom
  • ,
  • Christoph Kayser

      Affiliations

    • Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 Tübingen, Germany

Received 14 October 2009 ,Revised 16 December 2009 ,Accepted 21 December 2009.

References 

  1. Lauritzen M. Reading vascular changes in brain imaging: is dendritic calcium the key?. Nat Rev Neurosci. 2005;6:77–85
  2. Logothetis NK. What we can do and what we cannot do with fMRI. Nature. 2008;453:869–878
  3. Nair DG. About being BOLD. Brain Res Brain Res Rev. 2005;50:229–243
  4. Heeger DJ, Ress D. What does fMRI tell us about neuronal activity?. Nat Rev Neurosci. 2002;3:142–151
  5. Heeger DJ, Huk AC, Geisler WS, Albrecht DG. Spikes versus BOLD: what does neuroimaging tell us about neuronal activity?. Nat Neurosci. 2000;3:631–633
  6. Mukamel R, Gelbard H, Arieli A, Hasson U, Fried I, Malach R. Coupling between neuronal firing, field potentials, and FMRI in human auditory cortex. Science. 2005;309:951–954
  7. Arthurs OJ, Williams EJ, Carpenter TA, Pickard JD, Boniface SJ. Linear coupling between functional magnetic resonance imaging and evoked potential amplitude in human somatosensory cortex. Neuroscience. 2000;101:803–806
  8. Kayser C, Kim M, Ugurbil K, Kim DS, Konig P. A comparison of hemodynamic and neural responses in cat visual cortex using complex stimuli. Cereb Cortex. 2004;14:881–891
  9. Niessing J, Ebisch B, Schmidt KE, Niessing M, Singer W, Galuske RA. Hemodynamic signals correlate tightly with synchronized gamma oscillations. Science. 2005;309:948–951
  10. Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature. 2001;412:150–157
  11. Goense JB, Logothetis NK. Neurophysiology of the BOLD fMRI signal in awake monkeys. Curr Biol. 2008;18:631–640
  12. Caesar K, Thomsen K, Lauritzen M. Dissociation of spikes, synaptic activity, and activity-dependent increments in rat cerebellar blood flow by tonic synaptic inhibition. Proc Natl Acad Sci U S A. 2003;100:16000–16005
  13. Viswanathan A, Freeman RD. Neurometabolic coupling in cerebral cortex reflects synaptic more than spiking activity. Nat Neurosci. 2007;10:1308–1312
  14. Logothetis NK. The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. Philos Trans R Soc Lond B Biol Sci. 2002;357:1003–1037
  15. Oeltermann A, Augath MA, Logothetis NK. Simultaneous recording of neuronal signals and functional NMR imaging. Magn Reson Imaging. 2007;25:760–774
  16. Rauch A, Rainer G, Logothetis N. The effect of a serotonin induced dissociation between spiking and perisynaptic activity on BOLD fMRI. Proc Natl Acad Sci U S A. 2008;105(18):6759–6764
  17. Heeger DJ, Boynton GM, Demb JB, Seidemann E, Newsome WT. Motion opponency in visual cortex. J Neurosci. 1999;19:7162–7174
  18. Dubner R, Zeki SM. Response properties and receptive fields of cells in an anatomically defined region of the superior temporal sulcus in the monkey. Brain Res. 1971;35:528–532
  19. Qian N, Andersen RA. Transparent motion perception as detection of unbalanced motion signals: II. Physiology. J Neurosci. 1994;14:7367–7380
  20. Snowden RJ, Treue S, Erickson RG, Andersen RA. The response of area MT and V1 neurons to transparent motion. J Neurosci. 1991;11:2768–2785
  21. Snowden RJ, Treue S, Andersen RA. The response of neurons in areas V1 and MT of the alert rhesus monkey to moving random dot patterns. Exp Brain Res. 1992;88:389–400
  22. Logothetis NK, Guggenberger H, Peled S, Pauls J. Functional imaging of the monkey brain. Nat Neurosci. 1999;2:555–562
  23. Gold L, Lauritzen M. Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function. Proc Natl Acad Sci U S A. 2002;99:7699–7704
  24. Mitzdorf U. Properties of the evoked potential generators: current source-density analysis of visually evoked potentials in the cat cortex. Int J Neurosci. 1987;33:33–59
  25. Juergens E, Guettler A, Eckhorn R. Visual stimulation elicits locked and induced gamma oscillations in monkey intracortical- and EEG-potentials, but not in human EEG. Exp Brain Res. 1999;129:247–259
  26. Krekelberg B, Albright TD. Motion mechanisms in macaque MT. J Neurophysiol. 2005;93:2908–2921
  27. Qian N, Andersen RA, Adelson EH. Transparent motion perception as detection of unbalanced motion signals: III. Modeling. J Neurosci. 1994;14:7381–7392
  28. Lauritzen M, Gold L. Brain function and neurophysiological correlates of signals used in functional neuroimaging. J Neurosci. 2003;23:3972–3980

 This study was supported by the Max Planck Society.

PII: S0730-725X(09)00320-8

doi: 10.1016/j.mri.2009.12.028

Magnetic Resonance Imaging
Volume 28, Issue 8 , Pages 1087-1094 , October 2010