Interrelationships between 3-T-MRI-derived cortical and trabecular bone structure parameters and quantitative-computed-tomography-derivedbone mineral density

Issever, Ahi Sema; Link, Thomas M.; Newitt, David; Munoz, Thelma; Majumdar, Sharmila

doi:10.1016/j.mri.2010.06.003

« Previous Next »Magnetic Resonance Imaging
Volume 28, Issue 9 , Pages 1299-1305, November 2010

Interrelationships between 3-T-MRI-derived cortical and trabecular bone structure parameters and quantitative-computed-tomography-derivedbone mineral density

Ahi Sema Issever
- Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, China Basin, San Francisco, CA 94107, USA
- Department of Radiology, Charité Campus Mitte, Universitätsmedizin Berlin, 10117 Berlin, Germany
- Corresponding author. Department of Radiology, Charité Campus Mitte, Universitätsmedizin Berlin, 10117 Berlin, Germany. Tel.: +49 30 450 627 043; fax: +49 30 450 527 911.
Thomas M. Link
- Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, China Basin, San Francisco, CA 94107, USA
David Newitt
- Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, China Basin, San Francisco, CA 94107, USA
Thelma Munoz
- Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, China Basin, San Francisco, CA 94107, USA
Sharmila Majumdar
- Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, China Basin, San Francisco, CA 94107, USA

Received 16 November 2009; received in revised form 10 March 2010; accepted 10 June 2010. published online 05 August 2010.

Abstract

Recently, 3-T magnetic resonance imaging (MRI) has been introduced for bone imaging. Through higher signal-to-noise ratios, as compared to 1.5-T MRI, it promises to be a more powerful tool for the assessment of cortical and trabecular bone measures. The goal of our study was to compare MRI-derived cortical and trabecular bone measures to quantitative computed tomography (QCT)-derived bone mineral density (BMD). Using 3-T MRI in 51 postmenopausal women, apparent (app.) measures of bone volume/total volume, trabecular number (Tb.N), trabecular thickness (Tb.Th) and trabecular separation were derived at the distal radius, distal tibia and calcaneus. Cortical thickness (Ct.Th) was calculated at the distal radius and distal tibia. These measures were compared to QCT-derived BMD of the spine, hip and radius. Significant correlations (^⁎P<.05; ^⁎⁎P<.001; ^⁎⁎⁎P<.0001) were found between spine BMD- and MRI-derived Ct.Th (r_radius=.55, ^⁎P<.05; r_tibia=.67, ^⁎⁎⁎P<.0001) and app. Tb.N (r_radius=.33, ^⁎P<.05; r_tibia=.35, ^⁎P<.05) at the radius and tibia. Furthermore, within the first 10 mm at the radius, an inverse correlation for Ct.Th and app. BV/TV (r_6mm=−.56, P<.001; r_10mm=−.36, P<.05) and app. Tb.Th (r_6mm=−.54, P<.001; r_10mm=−.41, P<.05) was found.