Magnetic Resonance Imaging
Volume 28, Issue 9 , Pages 1390-1394, November 2010

N-Acetyl peak in MR spectra of intracranial metastatic mucinous adenocarcinomas

  • Xiang Liu

      Affiliations

    • Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, PO Box 648, Rochester, NY 14642, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 585 275 6363; fax: +1 585 473 4861.
    • ,
  • Barbara I. Germin

      Affiliations

    • Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    • ,
  • Jianhui Zhong

      Affiliations

    • Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, PO Box 648, Rochester, NY 14642, USA
    • ,
  • Sven Ekholm

      Affiliations

    • Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, PO Box 648, Rochester, NY 14642, USA

Received 10 June 2009; received in revised form 16 April 2010; accepted 25 June 2010. published online 27 August 2010.

Abstract 

Absence of N-acetylaspartate (NAA) is one important diagnostic criterion of MR spectroscopy (MRS) that may suggest that an intracranial mass lesion is a metastasis. We report two cases of histopathology-confirmed intracranial metastatic mucinous adenocarcinoma, which predominantly showed a large metabolite peak at 2.0 ppm, mimicking an NAA peak of normal brain tissue. This finding could be of help in the interpretation of MRS in cases of intracranial enhancing mass lesions, metastases or gliomas.

Keywords: Metastatic mucinous adenocarcinoma, MR spectroscopy, N-Acetylaspartate, Glycoprotein

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PII: S0730-725X(10)00172-4

doi:10.1016/j.mri.2010.06.015

Magnetic Resonance Imaging
Volume 28, Issue 9 , Pages 1390-1394, November 2010

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