Magnetic Resonance Imaging
Volume 28, Issue 10 , Pages 1514-1524, December 2010

Analysis of time reduction methods for magnetic resonance elastography of the brain☆

  • Matthew C. Murphy

      Affiliations

    • Mayo Clinic, Department of Radiology, Rochester, MN 55905, USA
    • ,
  • Kevin J. Glaser

      Affiliations

    • Mayo Clinic, Department of Radiology, Rochester, MN 55905, USA
    • ,
  • Armando Manduca

      Affiliations

    • Mayo Clinic, Biomathematics Resource, Rochester, MN 55905, USA
    • ,
  • Joel P. Felmlee

      Affiliations

    • Mayo Clinic, Department of Radiology, Rochester, MN 55905, USA
    • ,
  • Jon Huston III

      Affiliations

    • Mayo Clinic, Department of Radiology, Rochester, MN 55905, USA
    • ,
  • Richard L. Ehman

      Affiliations

    • Mayo Clinic, Department of Radiology, Rochester, MN 55905, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 507 284 7573; fax: +1 507 284 9778.

Received 13 October 2009; received in revised form 29 April 2010; accepted 25 June 2010. published online 03 September 2010.

Abstract 

Magnetic resonance elastography (MRE) uses a phase-contrast MRI technique to image shear wave propagation in tissue followed by the mathematical inversion of the equations of motion governing tissue mechanics to noninvasively image tissue stiffness. This work investigates the impact of various MR sampling strategies designed to reduce acquisition times on the accuracy of MRE inversions. The results indicate that brain MRE data can be significantly truncated while maintaining a mean global stiffness error less than 10%. The results also indicate that brain MRE data can be collected in as few as eight lines of k-space. This degree of data truncation is possible due to the relatively low spatial frequency content and low amplitude of the shear waves observed during brain MRE exams and will facilitate the design of rapid brain MRE protocols for future clinical investigations.

Keywords: MR elastography, Acquisition time, Shear waves, Brain elastography, Tissue stiffness

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☆ Grant support: EB001981.

PII: S0730-725X(10)00173-6

doi:10.1016/j.mri.2010.06.016

Magnetic Resonance Imaging
Volume 28, Issue 10 , Pages 1514-1524, December 2010

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