Magnetic Resonance Imaging
Volume 28, Issue 10 , Pages 1461-1467 , December 2010

Reversal of myo-inositol metabolic level in the left dorsolateral prefrontal cortex of rats exposed to forced swimming test following desipramine treatment: an in vivo localized 1H-MRS study at 4.7 T

  • Sang-Young Kim

      Affiliations

    • Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
    • Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul 137-040, South Korea
    • ,
  • Chi-Bong Choi

      Affiliations

    • Department of Radiology, Kyunghee University Medical Center, Hoekidong, Dongdaemungu, Seoul 130-702, South Korea
    • ,
  • Hyun-Sung Lee

      Affiliations

    • MRI Team, Korea Basic Science Institute, 804-1 Yangcheong-Ri, Ochang-Myun, Choongbuk, South Korea
    • ,
  • Sung-Ho Lee

      Affiliations

    • Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, South Korea
    • ,
  • Dong-Cheol Woo

      Affiliations

    • Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
    • Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul 137-040, South Korea
    • ,
  • Hwi-Yool Kim

      Affiliations

    • Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, South Korea
    • ,
  • Kwan-Soo Hong

      Affiliations

    • MRI Team, Korea Basic Science Institute, 804-1 Yangcheong-Ri, Ochang-Myun, Choongbuk, South Korea
    • ,
  • Chul-Hyun Lee

      Affiliations

    • MRI Team, Korea Basic Science Institute, 804-1 Yangcheong-Ri, Ochang-Myun, Choongbuk, South Korea
    • ,
  • Bo-Young Choe

      Affiliations

    • Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
    • Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul 137-040, South Korea
    • Corresponding Author InformationCorresponding author. Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea. Tel.: +82 2 2258 7233; fax: +82 2 2258 7760.

Received 19 October 2009 ,Revised 11 May 2010 ,Accepted 25 June 2010.

References 

  1. Moore CM, Breeze JL, Kukes TJ, et al. Effect of myo-inositol ingestion on human brain myo-inositol levels: a proton magnetic resonance spectroscopic imaging study. Biol Psychiatry. 1999;45:1197–1202
  2. Silverstone PH, McGrath BM, Kim H. Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. Bipolar Disord. 2005;7:1–10
  3. Kumar A, Thomas A, Lavretsky H, et al. Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. Am J Psychiatry. 2002;159:630–636
  4. Wyckoff N, Kumar A, Gupta RC, Alger J, Hwang S, Thomas MA. Magnetization transfer imaging and magnetic resonance spectroscopy of normal-appearing white matter in late-life major depression. J Magn Res Med. 2003;8:537–543
  5. Delamillieure P, Constans JM, Fernandez J, Brazo P, Dollfus S. Proton magnetic resonance spectroscopy (1H-MRS) of the thalamus in schizophrenia. Eur Psychiatry. 2000;15:489–491
  6. Delamillieure P, Constans JM, Fernandez J, et al. Proton magnetic resonance spectroscopy (1H MRS) in schizophrenia: investigation of the right and left hippocampus, thalamus, and prefrontal cortex. Schizophr Bull. 2002;28:329–339
  7. Taylor MJ, Selvaraj S, Norbury R, Jezzard P, Cowen PJ. Normal glutamate but elevated myo-inositol in anterior cingulated cortex in recovered depressed patients. J Affective Disorder. 2009;119:186–189
  8. Caetano SC, Fonseca M, Olvera RL, et al. Proton spectroscopy of the left dorsolateral prefrontal cortex in pediatric depressed patients. Neurosci Lett. 2005;384:321–326
  9. Coupland NJ, Ogilvie CJ, Hegadoren KM, Seres P, Hznstock CC, Allen PS. Decreased prefrontal myo-inositol in major depressive disorder. Biol Psychiatry. 2005;57:1526–1534
  10. Shimon H, Agam G, Belmaker RH, Hyde TM, Kleinman JE. Reduced frontal cortex inositol levels in post-mortem brain of suicide victims and patients with bipolar disorder. Am J Psychiatry. 1997;154:1148–1150
  11. Porsolt RD, Pichon ML, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266:730–732
  12. Borsini F, Meli A. Is the forced swim test a suitable model for revealing antidepressant activity?. Psychopharmacology. 1988;94:147–160
  13. Li CX, Wang Y, Gao H, Pan WJ, Xiang Y, Huang M, et al. Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy. Neurochem Res. 2008;33:2342–2349
  14. Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci. 2002;23:238–245
  15. Joffe RT, Richter MA. Allergic skin eruption with desipramine treatment. Can J Psychiat. 1987;32:695–696
  16. Lopez-Rubalcava C, Lucki I. Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test. Neuropsychopharmacol. 2000;22:191–199
  17. Gruetter R. Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn Reson Med. 1993;29:804–811
  18. Tkác I, Starcuk Z, Choi IY, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med. 1999;41:649–656
  19. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672–679
  20. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 2001;14:260–264
  21. Ross BD. Biochemical considerations in 1H spectroscopy: glutamate and glutamine; myo-inositol and related metabolites. NMR Biomed. 1991;4:59–63
  22. Thomas MA, Huda A, Guze B, Curran J, Bugbee M, Fairbanks L, et al. Cerebral 1H MR spectroscopy and neuropsychologic status of patients with hepatic encephalopathy. AJR Am J Roentgenol. 1998;171:1123–1130
  23. Perry TL, Hansen S, Berry K, Mok C, Lesk D. Free amino acids and related compounds in biopsies of human brain. J Neurochem. 1971;18:521–528
  24. O'Donnell T, Rotzinger S, Nakashima TT, Hanstock CC, Ulrich M, Silverstone PH. Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain. Brain Res. 2000;880:84–91
  25. Moore GJ, Bebchuk JM, Parrish JK, et al. Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic–depressive illness. Am J Psychiatry. 1999;156:1902–1908
  26. McGrath BM, Greenshaw AJ, McKay R, Slupsky CM, Silverstone PH. Lithium alters regional rat brain myo-inositol at 2 and 4 weeks: an ex-vivo magnetic resonance spectroscopy study at 18.8T. NeuroReport. 2006;17:1323–1326
  27. Cecil KM, DelBello MP, Sellars MC, Strakowski SM. Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorder. J Child Adolesc Psychopharmacol. 2003;13:545–555
  28. Haydon PG. Glia: listening and talking to the synapse. Nat Rev Neurosci. 2001;2:185–193
  29. Soares JC, Mann JJ. The anatomy of mood disorders—review of structural neuroimaging studies. Biol Psychiatry. 1997;41:86–106
  30. Farchione TR, Moore GJ, Rosenberg DR. Proton magnetic resonance spectroscopic imaging in pediatric major depression. Biol Psychiatry. 2002;52:86–92
  31. Massana G, Gastó C, Junqué C, Mercader JM, Gómez B, Massana J, et al. Reduced levels of creatine in the right medial temporal lobe region of panic disorder patients detected with 1H magnetic resonance spectroscopy. NeuroImage. 2002;16:836–842
  32. Coplan JD, Mathew SJ, Mao X, Smith ELP, Hof PR, Coplan PM, et al. Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma. Psychiatry Res. Neuroimaging. 2006;147:27–39
  33. Gabbay V, Hess DA, Liu S, Babb JS, Klein RG, Gonen O. Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study. Am J Psychiatry. 2007;164:1881–1889
  34. Frye M, Watzl J, Banakar S, O'Neill J, Mintz J, Davanzo P, et al. Increased anterior cingulated/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology. 2007;32:2490–2499

PII: S0730-725X(10)00176-1

doi: 10.1016/j.mri.2010.06.019

Magnetic Resonance Imaging
Volume 28, Issue 10 , Pages 1461-1467 , December 2010

Article Tools

* Image Usage & Resolution